DOSAGE AND ADMINISTRATION
Lyrica (Pregabalin) is given orally with or without food.
When discontinuing LYRICA, taper gradually over a minimum of 1 week.
Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
The maximum recommended dose of LYRICA is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Because LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function.
Although LYRICA was also studied at 600 mg/day, there is no evidence that this dose confers additional significant benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 300 mg/day is not recommended.
Capsules: 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, and 300 mg Oral Solution
The following serious adverse reactions are described elsewhere in the labeling:
Increased Risk of Adverse Reactions with Abrupt or Rapid Discontinuation
Suicidal Behavior and Ideation
Dizziness and Somnolence
Creatine Kinase Elevations
Decreased Platelet Count